Does Trulicity cause weight loss? Medically reviewed by Carmen Pope, Senior Medical Editor, B. Pharm. Trulicity is not a weight loss drug, but some people may lose weight. People lost, on average, two to six pounds while taking Trulicity. However, 15 to 30% gained weight. One of the ways Trulicity works is by helping to make you feel full after a meal. People more likely to lose weight include those with a higher starting weight and a longer duration of gastrointestinal side effects. Trulicity (dulaglutide) is an injectable medicine that is used to improve blood sugar control in adults over the age of 18 with type 2 diabetes. Trulicity is injected under the skin once a week, preferably on the same day each week at the same time. Each injection will help control blood sugar levels for one week. Trulicity is only effective in people with type 2 diabetes. How much weight loss occurs with Trulicity? Research has shown that many people lose, on average, two to six pounds while taking Trulicity.
However, some people gained weight. Was associated with a greater weight loss (3.23kg on average) compared to insulin glargine in 588 patients also taking insulin lispro. Although overall treatment with GLP-1 receptor agonists is associated with weight loss, this varies among individuals, and 15 to 30% of people will gain weight. People more likely to lose weight include those with a higher starting weight and a longer duration of gastrointestinal side effects. Which GLP-1 drug is best for weight loss? Trulicity vs Ozempic: Which is right for you? Trulicity vs Mounjaro: How do they compare? How does Trulicity work? Trulicity belongs to a class of medicines called GLP-1 receptor agonists. It may also be called an incretin mimetic. Trulicity works by mimicking the functions of natural incretin hormones in the body that help keep blood sugar levels under control, especially immediately following a meal. Incretin hormones are gut peptides that are secreted from the stomach when food is eaten.
They also stimulate the secretion of insulin in response to high blood glucose levels. Two incretin hormones are known as GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1). In people with type 2 diabetes, this natural incretin effect is diminished or no longer present. However, it can be stimulated with pharmacological agents, such as Trulicity. Trulicity shares 90% of the same structure as human GLP-1 but is man-made. It has been modified so that it can last in the body for a long time (approximately one week) and not be broken down by an enzyme naturally present in the blood, called dipeptidyl peptidase-4 or DPP-4. Trulicity acts like GLP-1 and MedicGLP Support binds to GLP-1 receptors, stimulating insulin release from the pancreas, MedicGLP Official Support reducing the amount of glucose that the liver produces, and making you feel full by slowing gastric emptying. Does Trulicity need to be refrigerated? Trulicity should be stored in a refrigerator until you need to use it.
You can leave Trulicity out of a refrigerator for up to 14 days and MedicGLP Weight Support still use it. Trulicity and diet: What foods should you avoid? You don’t have to avoid any specific foods because of Trulicity itself, MedicGLP Support but greasy, very sweet, or very large meals can make nausea, heartburn, or other stomach side effects worse. It’s best to limit those while focusing on smaller, balanced meals with lean protein, fiber, and plenty of fluids. How do you use/inject Trulicity? To use the Trulicity Pen remove the cap of the pen and hold the pen straight up and down on the skin before pushing the green injection button. You should hear a click, followed by a second click, 10 to 15 seconds later once the injection has finished. Trulicity is injected under the skin once a week into the thigh, stomach area, or upper arm. Can Trulicity be injected cold? Can Trulicity be used with insulin?