Sildenafil
The major circulating metabolite results from Ndesmethylation of sildenafil, and is itself foster metabolized. This metabolite has a PDE selectivity profile standardised to sildenafil citrate and an in vitro strength for PDE5 about 50% of the rear do drugs. Plasma concentrations of this metabolite are or so 40% of those seen for sildenafil, so that […]
