Can Higher-Dose Trulicity Pack a Stronger Punch Than Currently Approved Doses? What the trial is testing: This study will test the effectiveness of different doses of Trulicity (dulaglutide), a GLP-1 agonist, in addition to metformin for type 2 diabetes. Trulicity is a once-weekly injectable treatment already FDA approved for type 2 diabetes. Its recommended dose is 0.75 – 1.5 mg per day, delivered in a single-use auto-injector device. This new study will examine the safety and effectiveness of larger dosages, 3 and healthy lifestyle support 4.5 mg. It will be particularly interesting to see the results from the dose that is three times as higher – the 4.5 mg. What the trial is measuring: The change in A1C and change in body weight. To test safety, it will also record the number of hypoglycemia (low blood sugar) events. Why is this new/important? GLP-1 agonists have been shown to help with weight loss in addition to lowering glucose levels.
The current recommended dose of Trulicity is safe and effective, but increased doses may be even more beneficial. Particularly with long-acting drugs like once-weekly Trulicity, finding the optimal dose can be a bit tricky for some patients. Earlier phase 2 studies testing the higher-dose Trulicity against the standard dose did find that A1C was lowered slightly more, along with more weight loss. There is a precedent for investigating higher doses for a drug – Victoza and Saxenda. Victoza is another Medic GLP Supplement-1 agonist (liraglutide) approved for the treatment of type 2 diabetes and comes in 1.2 or 1.8 mg doses; Saxenda is nearly double that at 3 mg of liraglutide and was found to be so effective on the weight-loss front that it is now marketed as a weight-loss drug. That said, do keep in mind that this trial is not testing this drug as a weight-loss drug specifically. Dr. Jeff Emmick, Vice President of Product Development at Lilly, emphasized that Lilly is looking to offer more choices to people who need additional support in managing their diabetes, particularly as type 2 has long been viewed as a progressive condition. If this larger trial has positive findings, the recommended dose of Trulicity could possibly change for some people depending on their diabetes management needs. Trial locations: For this big study opportunity, Lilly is enrolling 1,800 participants through locations in 32 states and 16 countries; click here for the full list and specific contacts. Where to get more information: Contact your closest site via the information listed under trial locations.
Science continues to prove that the old adage “you are what you eat” is profoundly true. This is because you have trillions of microorganisms living in your gut, which are directly responsible for nearly every aspect of your health. These microbes make up what’s called your “gut microbiota.” They are especially influential in determining your likelihood of gaining excessive weight, becoming obese, and developing obesity-related diseases like diabetes, heart disease, and premature death. The gut microbiome (the expressed genes of your gut microbiota) plays a major role in your metabolism through energy production, storage, and expenditure. So, lifestyle weight support it’s no surprise that science has found a strong connection between gut microbiome imbalance and metabolic syndrome. Yikes! If you have the wrong mix of microbes, it could be making it tough for you to get your health on track! Did you know: Scientists can actually look at your gut microbiome composition and tell with 90% accuracy if you are obese or lean. That’s pretty impressive, isn’t it?
1. Unable to lose weight and keep it off? 2. Struggling to fight cravings? 3. Sick of starving yourself for weight loss? 4. Baffled as to why no diet seems to really work for you? Depending on the composition of your gut microbiome, your microbes can either boost your health or weigh you down (figuratively and literally). The good news is this: You have control over these little guys with every bite you eat. Diet has the power to change the landscape of your gut microbiome. So, if you’ve tried multiple diets and can’t seem to get the results you want, it’s time to look into your gut microbiome.Will You Lose Weight Naturally on an Individualized Diet? If you’ve been struggling to lose weight and keep it off – it could be your gut microbiome. While Viome doesn’t guarantee weight loss, it has been an exciting result many of our customers have reported. “Fiona’s update day 37!
We know weight loss can be tough. Find out if your weight struggles are due to a gut microbiome imbalance with Viome – and let’s tip the scales in your favor. Your gut microbes actually digest much of your food for you. When your gut microbiota help digest your food, they turn it into nutrients, neurotransmitters, vitamins, hormones, and more. Through these metabolites, the composition of your gut microbiome influences nearly every metabolic activity. It’s accurate to think of your gut microbiome as an organ that’s part immune system and part energy regulator. If your gut microbiome is imbalanced, certain bacteria end up working to protect themselves from the harsh environment and are not able to help you. In the worst case scenario, you can have microbiota adding to your health problems, making it harder for you to get healthy and lose weight. Viome’s metatranscriptomic technology has allowed us identify microbial pathways and functions, specifically those that influence weight loss or gain.